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Under hyperglycemic conditions, INS-1 cells exposed to the NLCs released more insulin than the control untreated cells and the unformulated-extract-treated cells (131)

The goal: achieve MC1R selectivity (for controlled melanogenesis in research models) without MC4R activation (which drives the cardiovascular and autonomic side effects)

Semaglutide (Ozempic, Wegovy, Rybelsus): A specific type of GLP-1 receptor agonist that has a 94% similarity to human GLP-1 but is designed to last much longer in the body, requiring less frequent dosing

GLP-1 receptor agonists and cardiovascular outcome trials: An update

Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, et al