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Nauck M, Stockmann F, Ebert R, Creutzfeldt W: Reduced incretin effect in type 2 (non-insulin-dependent) diabetes

Clinical trials have shown that GLP-1R agonists increase microvascular blood volume and flow in cardiac muscle, and these effects are preserved in obese individuals with vascular insulin resistance

Alcohol before bed may make you sleepy and help you fall asleep faster, but it can also cause abnormal sleep architecture and disrupt circadian rhythms

Semaglutide has a cumulative exposure of over 22 million patient-years." "We will continue to invest in a variety of disease states including diabetes, chronic kidney disease, obesity, CV disease, liver disease, and Alzheimers disease, as seen in our robust clinical development programs and outcome studies," the statement continued

Nat Chem Biol (2016) 12:5318