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Importantly, prolonged or excessive substance exposure increases vulnerability to negative affective states, including depression, yet the pathophysiological mechanisms bridging addiction and depression remain incompletely understood

GSH increases activation of cytotoxic T cells in vivo , and adequate functioning of T lymphocytes and other cells depends upon cellular supplies of cysteine (Edinger and Thompson, 2002

Discovery of bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) Journal of medicinal chemistry

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Eosinophils increase airway sensory nerve density in mice and in human asthma