When people with diabetes were given the glutathione precursors cysteine and glycine, their levels of glutathione went up, and their oxidative stress went down, suggesting that GSH supplementation may be very beneficial in preventing type 2 diabetes-related oxidative stress and tissue damage
Some have proposed that ammonia is converted to glutamine, which causes cerebral edema either directly by its osmotic effect 37,38 or indirectly by decreasing other osmolytes, thereby promoting water retention
These results suggest that WRKY transcription factors participate in the regulation of GSTU11 and other GSTs , in concert with a large number of other transcription factors and signaling compounds
And in studies, people with high levels of vitamin C typically have high glutathione levels, as well
The absorption and efficacy of glutathione supplements depend on several factors, including whether they are taken on an empty stomach or with food, the influence of other supplements or medications, individual differences in metabolism and bioavailability, and the role of glutathione precursors
