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In the second step of biosynthesis, glutathione synthetase (GS) adds the final amino acid, glycine, to complete the glutathione molecule

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Considering the pivotal function of ferroptosis in OA, targets such as transient receptor potential vanilloid 1 (TRPV1) [27,28], glutathione peroxidase 4 (GPX4) [29], nuclear factor erythroid 2-related factor 2 (NRF2) [30], acyl-CoA synthetase long-chain family member 4 (ACSL4) [31], and nuclear coactivator adaptor 4 (NCOA4) [32] have surfaced as prospective regulators of ferroptosis and modulators of OA advancement

10.1016/j.bcp.2024.116102 113 ZhaoW.JinG.SunW.WuC.YangQ.XueL.et al (2025a)

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