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Deficiency causes megaloblastic anemia and subacute combined degeneration of the spinal cord

The dopamine in this pathway speaks to the subcortical brain areas responsible for initiating movement, therefore a lack of dopamine causes PD patients to have rigidity or akinesia. A popular treatment for PD, L-dopa, is a precursor to dopamine, and helps make up for lost dopamine neurons

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Additionally, it demonstrated the differential expression of oxidative stress-related genes, such as SOD1, induced by ketamine (Bosnjak et al., 2012)