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Livers of WT mice fed the HF-SAAR diet had a higher citrate M+3-to-pyruvate M+3 ratio relative to WT mice fed a HF-CTRL and KO mice fed a HF-SAAR diet (Fig

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Furthermore, according to RNA-sequencing analysis, the circular RNA IARS (circ-IARS) is overexpressed in hepatocellular carcinoma (HCC), while an in-depth study has found that circ-IARS-silenced cells show a substantial decrease in Fe 2+ and an evident increase in intracellular GSH