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True indicator of semaglutide effectiveness is consistent, progressive weight loss over 48 weeks combined with reduced hunger cues

10.1056/NEJMoa1911303 [DOI] [PubMed] [Google Scholar] 78

If your last meal is dinner at 6:00 PM and you go to bed at 10:00 PM, that gives your stomach 4 hours to process food before you lie down

Doi, K., & Uetsuka, K

Overall, these limitations might encourage the search of different approaches, which might combine a more favorable compliance and safety, with acceptable efficacy and with more affordable treatment regimens, and might be therefore particularly suited in a minority of patients experiencing one or more hindrances to PDE5i treatment