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Both familial (fALS, 510% of cases) and sporadic (sALS) forms show similar clinical and pathological features, with overlapping cognitive and behavioral changes, particularly frontotemporal-like symptoms, as well as progressive bulbar and limb motor dysfunction

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[Physiological functions of carnitine and carnitine transporters in the central nervous system]

doi:10.1074/jbc.M209372200

Sustained appetite suppression and weight loss in obese rhesus monkeys treated with a long-acting GLP-1 derivative, NN2211