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GLP-1R agonists can stimulate cell proliferation in vitro by activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) and 5 adenosine monophosphateactivated protein kinase/mechanistic target of rapamycin signaling pathways and the inactivation of Forkhead box protein O1 (FOXO1) in pancreatic cell lines as well as in cells in human islets of Langerhans

In most cases, after the shot, applying a cold compress to the injection site can help reduce swelling and numb the area, alleviating pain

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Pregnancy and Breastfeeding Both are contraindicated in pregnancy and should be stopped at least 2 months before planned conception

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