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In this regard, our data showed a similar pharmacological profile on glucose-dependent insulinotropic polypeptide receptor (GIPR), with similar efficacy than with GLP-1R, indicating a dual agonist profile rather than strict GLP-1R selectivity, as shown in Figure 6

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Interestingly, recent research has highlighted a dual role for Nrf2 in cancer: while basal Nrf2 activity aids normal cell defense, cancer cells can exploit Nrf2 for chemoresistance

Second, inositol functions as a secondary messenger in insulin signaling pathways and supports lipid transport within cells

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