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Studies in mice using several tissue-specific targeting strategies have confirmed that the elevation of circulating DPP4 in obesity is liver derived (2224), suggesting that DPP4 produced in the liver may primarily contribute to the progression of NAFLD (25)

#obesity #drugdiscovery #pharma Novo Nordisk's cagrilintide shows promise in Phase 3 trial Last week I covered Lillys oral GLP-1

reuteri ) significantly lowered Th1-mediated inflammation accompanied by reduced levels of IFN- and a notable reduction in serum anti-dsDNA autoantibody titers, which are one of the hallmark indicators for lupus severity ( Figure 2 ) (120)

Participants taking oral semaglutide experienced clinically meaningful weight loss, with average reductions exceeding 16% when paired with diet and exercise, and substantial weight loss even without intensive lifestyle modification

The latter was already observed within 3 days of treatment