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Meta-analyses report a pattern of ALC deficiency in DPN patients 2 and a growing number of randomized controlled trials on ALC suggests that ALC is not only safe and effective, but also outperforms placebo in reducing diabetes-related neuropathic pain 3,4

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The localized heat generated by RF can also temporarily increase lipid fluidity in the stratum corneum, promoting fusion of liposomal bilayers with disrupted skin lipids and enhancing the release of encapsulated drugs [261]

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However, unapproved high-dose or counterfeit products may contain unsafe ingredients that can strain liver or kidney function so quality control is crucial