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Availability of data and materials All data relevant to this review are included in the text, references, and figures

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No published case reports or pharmacovigilance signals specifically document seizures triggered by the liraglutide-bupropion combination

Spironolactone (10-80 mg/mL, subcutaneous injection) increases pain behavior in a dose-dependent manner in Male Swiss albino mice thermal and electrical pain models, but reduces inflammatory visceral pain caused by intraperitoneal acetic acid and chemical pain caused by plantar capsaicin [3]