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In healthy women of child-bearing age, the protective mucosa in the vagina is populated with microflora typically dominated by lactobacilli and their dominance over pathogenic anaerobes is positively associated with vaginal health (1)

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Certain strains, including Lactobacillus acidophilus , inhibit multiple proinflammatory pathways, such as PI3KAKTNF-B, via their metabolites ( In summary, by modulating immune-cell function, rebalancing lymphocyte subsets, and reprogramming core signaling networks, probiotics operate through an integrated cellular-to-molecular network to correct immune dysregulation in UC, offering a multi-target strategy to restore intestinal immune homeostasis