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Topline data from the Phase 3 REDEFINE 1 trial found CagriSema, a fixed-dose combination of cagrilintide 2.4 mg and semaglutide 2.4 mg, achieved superior weight loss versus placebo in adults with 1 Announced by Novo Nordisk on December 20, 2024, the trial achieved its primary endpoint with a superior weight loss of 22.7% after 68 weeks of treatment but still fell short of the 25% weight loss expected by the company in earlier discussions
Pharmacologic GLP-1 RAs are synthetic analogs designed to resist degradation by dipeptidyl peptidase-4 (DPP-4), thereby prolonging their half-life
In the full episode, I cover: -Time-restricted eating: minimal effect beyond calorie control, implications for protein intake, and practical considerations for implementing it -Ultra-processed foods: definitions, real-world risks, and practical guidelines for smarter consumption -Hormone replacement therapy: preparing for menopause and thinking clearly about HRT in women, and the indications and benefits of testosterone replacement in aging men -Why I recommend earlier and more aggressive screening tests than guidelines suggest: colonoscopies, coronary imaging, PSA, Lp(a), and low-dose CT scans, and more This AMA episode (Ep
It comprises glutamine, cysteine, and glutamic acid