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As far as REWIND, I don't want to speculate on the particular indication that we will get

Patients with a history of chronic pancreatitis, pancreatic cancer, or other significant pancreatic disorders may not be suitable candidates for this therapy

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Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition

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