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Synthetic cathinones also impair mitochondrial function, reduce ATP production, and increase the opening of mitochondrial permeability transition pores

Short-term antiemetic use may be considered for persistent nausea, but metoclopramide should be used for a maximum of 5 days due to risk of side effects, and domperidone requires cardiac risk assessment

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Meanwhile, annual US deaths from opioid overdose are 109,000 per year, deaths from excess alcohol use are 178,000 per year, and deaths from smoking are 480,000 per year

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