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Do not use as a substitute for a balanced and varied diet

A history of heart attack, stroke, angina, coronary artery disease, or peripheral arterial disease qualifies

What microdosing looks like Rather than starting at 2.5 mg, a microdosing approach might begin at 1.0 to 1.5 mg and increase in smaller increments: This approach requires compounded tirzepatide since brand-name pens do not allow sub-2.5 mg dosing

They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain