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Also, the origin of OPCs is traced early in the formation of the mammalian CNS and comprises multiple and sequential waves of production of OPCs that end in colonization and positioning in the cortex and spinal cord (Kessaris et al., 2006

Interestingly, BBB efflux transport of GCs, including guanidinoacetate and creatinine, is negligible, though the BBB has a variety of efflux transport systems for synthetic precursors of GCs, such as amino acids and neurotransmitters