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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 10% by weight of the poloxamer

Side effects are uncommon and typically mild, such as temporary redness or irritation with topical use or slight discomfort at the injection site

And I was TERRIFIED

In addition to biocompatibility, biodegradation, bioadhesiveness, and biofunctionality of the NDBs, several drawbacks must be addressed, such as low stability, low melting point, high surface tension, structural complexity, and well-known immunological response from organisms (Ige et al., 2012

There is no risk of exceeding regulatory limits