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The three possibilities Base case: EVOKE shows a modest but convincing difference on CDRSB at two years with slowing of cognitive impairment in the range that we already accept from gold standard treatment

We imputed ten datasets by predictive mean matching for continuous variables, logistic regression for dichotomous variables, and multinomial logistic regression for polytomous variables

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The observed clinical benefits appear to stem primarily from weight loss rather than direct analgesic mechanisms

Vehicle residence time is the second lever and is largely pathway-independent: a formulation cleared by mucociliary action before absorption is complete underperforms regardless of how well ionization or enhancer selection is optimized