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DNA polymerases replace the lesion with the correct sequence, and a DNA ligase completes the repair.[47,63] An XP variant that is associated with pathogenic variants in POLH (XPV) is responsible for approximately 10% of reported cases.[64] This gene encodes for the error-prone bypass polymerase (polymerase eta) which, unlike other genes associated with XP, is not involved in nucleotide excision repair