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The market is driven by the increasing prevalence of obesity and type 2 diabetes throughout the world, the effectiveness of GLP-1 agonists in terms of significant weight loss and glucose management, and active consumer promotion campaigns and reimbursement coverage

Nature 394 , 395399 (1998)

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Despite the presence of DPP-4 inhibitor we were able to detect cleavage of both monotreme GLP-1 peptides (Supplementary Fig