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In contrast, compounds such as ketamine and classical psychedelics produce rapid antidepressant effects by enhancing structural plasticity via glutamatergic systems and neurotrophic signalling [11,12,13,14,15,16], thereby calling into question the sufficiency of a 5-HT-centric model of MDD

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It is notable that the beneficial effect of ARA 290 appears to be sustained for at least the 28-d follow-up period

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