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222 As a Lewy body constituent and a partner of alpha-synuclein, synphilin-1 interacts with -synuclein to diminish the degeneration of neurons in the brain and motor abnormalities in mice with the A53T mutation

By increasing serotonin availability in synaptic spaces, sertraline helps to: Improve mood and reduce symptoms of depression Alleviate anxiety in conditions such as panic disorder, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD) Reduce symptoms in social anxiety disorder While sertraline is also commonly used for generalised anxiety disorder (GAD) in the UK and is recommended by NICE guidelines, this use is technically off-label

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Participants receiving semaglutide 2.4 mg weekly lost significantly more weight than those on placebo, with benefits observed across age groups and BMI ranges