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Intrinsic neuroprotection refers to the activation of endogenous cellular programs that bolster neuronal survival under stress

Vogel DG, Malekzadeh MH, Cornford ME, Schneider JA, Shields WD, Vinters HV (1990) Central nervous system involvement in nephropathic cystinosis

How AOD-9604 Fat Cell Targeting Compares to Other Approaches Understanding how AOD-9604 targets fat cells becomes clearer when compared to other fat loss mechanisms and interventions

Preclinical results do not guarantee human effects

NAPQI is neurotoxic : Crosses the placenta, depletes fetal brain glutathione, generates oxidative stress, and triggers cell death in neural tissue at doses below those causing maternal liver toxicity