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Changes in gene expression levels of glutamate-cysteine ligase (GCL), glutathione peroxidase (GPx1), glutathione reductase (GR) and glutathione synthetase (GS) genes were analyzed by real-time qPCR on ABI PRISM 7500 (Applied Biosystems)

Injection site reactions including minor redness, swelling, or tenderness occur in some users but typically resolve within hours

Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23

This matters because of the time scale

For some, this manifests as a dull headache or a feeling of "heaviness" in the head