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This pathway: Promotes synaptogenesis the formation of new synaptic connections between neurons Mimics BDNF activity downstream effects on neuronal survival, plasticity, and growth Enhances hippocampal function the hippocampus is critical for memory formation and retrieval Crosses the blood-brain barrier unlike BDNF itself, Dihexa is small enough to penetrate the BBB The result is enhanced neural plasticity the brain's ability to reorganize and form new connections, which underlies learning, memory, and cognitive performance

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Farber PM, Arscott LD, Williams CH Jr., Becker K, Schirmer RH

Thus, identifying novel therapeutics that target multiple pathways and genes associated with AD represents a promising strategy for treatment