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We report herein a series of pharmacological and molecular studies in two validated mouse models of PCOS, generated by gestational (PNA) or postweaning (PWA) androgenization, addressing the effects of GLP1-based multi-agonist therapies on metabolic and reproductive traits of PCOS
Each hormone plays a specific role in how your body manages energy and hunger
It affects skeletal muscle (impaired glucose uptake), the liver (impaired glycogen synthesis), and paradoxically, the ovaries (which remain sensitive to insulin's androgen-stimulating effects)
The most common suspected adverse event reported was subacute thyroiditis, followed by Graves disease with other incidental reports of painful thyroiditis, silent thyroiditis, concurrent Graves disease and subacute thyroiditis, thyroid eye disease, overt hypothyroidism, atypical subacute thyroiditis, and painless thyroiditis with thyrotoxic periodic paralysis (133)