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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

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A BMI of 27 or greater (Overweight) plus at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol

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