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Without treatment, vitamin B12 deficiency can cause physical, neurological and psychological problems

Nez-Vergara et al

When to Be Concerned In a research context, further evaluation may be warranted if observations include: Rapidly expanding redness beyond the injection site Severe or escalating pain Persistent swelling lasting multiple days Signs of infection (increasing warmth, spreading redness, discharge) Systemic symptoms such as generalized hives, shortness of breath, dizziness, or facial swelling Severe or systemic reactions should be treated as medically significant and require appropriate clinical evaluation

doi: 10.1038/nchembio.2239 55 EnkeUSeyfarthLSchleussnerEMarkertUR

Individuals who are pregnant or breastfeeding, those with a history of certain cancers (due to the peptides ability to stimulate blood vessel growth), or those with copper metabolism disorders such as Wilsons disease should avoid this therapy