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The difference between elevated or unchanged GLP-1 levels in obese patients may be related to differences in metabolic status and detection methods, but the significant correlation between GLP-1 and lipid metabolism suggests that it can control weight and regulate lipid metabolism in HF diet groups, and GLP-1 has the potential to treat obesity caused by HF diet [102]

Therefore, an advanced time-resolved, non-invasive bio-imaging technique is required to measure temporal variations of the permeation and diffusion phenomena of drug solution in subcutaneous tissue

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While liver damage markers were increased in the serum of Gclc KO mice, their levels fell within the physiological range reported in healthy mice 38

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