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(27) Chang et al

Two years of continued insulin resistance, elevated adiposity, and associated cardiovascular risk is a real cost

Glucagon-like peptide-1 (GLP-1) receptor agonistssuch as Ozempic , Wegovy , and Zepbound have become game changers for managing type 2 diabetes and weight loss

Combining semaglutide with other peptide pathways, like those targeted by tirzepatide (which activates both GLP-1 and GIP receptors), can activate fresh pathways and bypass this adaptation