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These symptoms typically occur during dose escalation and often improve with continued therapy

Recently, vinca alkaloids have demonstrated to exert their neurotoxicity via activation of spinal cord glia (i.e., astrocytes and microglia), offering an option for the treatment of CIPN through pharmacological antagonism of this phenomenon

J Diabetes Investig 11:15511563 Ott C, Jumar A, Striepe K, Friedrich S, Karg MV, Bramlage P, Schmieder RE (2017) A randomised study of the impact of the SGLT2 inhibitor dapagliflozin on microvascular and macrovascular circulation

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