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Early mutagenesis studies of the Arabidopsis GS identified a putative glycine-rich loop as important for activity (Wang and Oliver, 1997a,b), which was identified in later structural studies as forming part of the active site (Galant et al., 2009)

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These previous studies, however, did not directly confirm the functional roles of defensin genes in plant stress tolerance under various abiotic stresses, underscoring the need for further mechanistic studies to validate their contributions

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PMID: 25756278 11 Evaluation of a New Sublingual Methylcobalamin Dosage Regimen for Childhood Vitamin B12 Deficiency