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The applicant also asserted that CMS's literal application of its example that a pacemaker is integral to the procedure of implantation of a pacemaker is overly simplistic and suggests that any feature beyond the basic function of a device could be considered non-integral. In addition, the applicant asserted that CMS has previously deviated from this approach when determining transitional pass-through payment status

Regarding mitochondrial dysfunction involved in AD pathophysiology, it includes disturbances in oxidative phosphorylation (OXPHOS), and impaired energy metabolism as well as excess generation of ROS, altered mitochondrial biogenesis, transport and dynamics (68)

beta2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

Hum Pathol 1986

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