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Providers consider appetite patterns, existing medical conditions, lifestyle habits, side effect tolerance, and long-term health goals before recommending treatment

All safety discussions apply strictly to research use

Most participants who experienced nausea during the initial titration phase reported significant improvement or complete resolution by weeks 4 to 8 at a stable dose

Genomic DNA from peripheral blood cells of surviving recipients at five months post-transplantation was analyzed using primers specific to the Y chromosome

Patients who can become pregnant are carefully informed about the risk of congenital disabilities and must complete the required iPLEDGE steps to confirm they understand the safety guidelines before starting treatment