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[5] Disruption of these pathways leads to accumulation of homocysteine and methylmalonic acid, metabolic signatures linked to megaloblastic anemia and demyelinating neuropathy

The association between mitochondria-derived metabolite MMA and mortality risk During the median follow-up of 7.92 years, 980 (49.6%) patients died

Evidence level: Misleading framing Sources: ClinicalTrials.gov exact-name search, accessed 2026-07-12 How to read this: The absence of human trials means human adverse effects are largely unknown

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