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It can also be a minor annoyance, such as a mild headache
Weight loss was a well known side effect, which is partly what led to newer versions being licensed specifically for weight management
Vilsboll T, Krarup T, Madsbad S, Holst JJ (2003) Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects
Studies show that the synthetic versions of GLP-1 (semaglutide and tirzepatide) used in medications can reshape the gut microbiome composition
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