Qu Y, Yamada T, Aoi N, Morikura I, Fuchiwaki T, Hotta Y, et al
Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, Waxman DJ
Two compounds frequently discussed in this context are NAD (nicotinamide adenine dinucleotide) and Glutathione
With age, GSH levels decrease by up to 50% compared to young subjects, contributing to increased oxidative stress and chronic low-grade inflammation (inflammaging). In the anti-ageing field, GSH IV acts on three main levels: direct neutralisation of free radicals and protection of dermal collagen, modulation of inflammation through NF-B inhibition, and reduction of melanogenesis through tyrosinase inhibition with clinically observable effects on skin tone and luminosity. The most robust clinical evidence concerns neuroprotection (improvement of motor symptoms in Parkinson's disease) and protection from chemotherapy-induced neuropathy
Diabetic retinopathy complications have been reported, particularly in patients with pre-existing retinopathy experiencing rapid improvements in glycaemic control
