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The propensity score was constructed from age at the index date (continuous), sex, race, region, number of RMS relapses in the preindex period (0, 1, 2+), prior DMT in the preindex period, RMS disability in the preindex period, Deyo-Charlson comorbidity index (DCCI) in the preindex period (continuous), and Psychiatric Diagnosis Group index in the preindex period (continuous)

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In addition, Ang-1 mimetic and the inhibition of circulating Ang-2 could reduce vascular permeability [78]