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Studies have found that sevoflurane inhalation may induce mitochondrial mPTP opening, ROS increase, and reduction in ATP production by increasing intracellular calcium ion concentration, leading to mitochondrial dysfunction and structural damage [6]

Removes excess free radicals that will cause abnormal function of brains and organs

Soluble cytokine factors Studies have shown that senescent hepatocytes secrete the paracrine senescence-related factor 13-Hydroxyoctadecadienoic acid, which acts on surrounding hepatocytes to promote hepatic steatosis

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Upadhyay J, Polyzos SA, Perakakis N, Thakkar B, Paschou SA, Katsiki N, et al