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Lesions of dopamine nigral neurons not only result in depression-like behavior (in the substantia nigra pars compacta) but also lead to a cascade of functional modifications on the activity of basal ganglia circuits, with the dysregulation of the glutamate system.12,13 This pathophysiological mechanism is also shared with Parkinson's disease, with the destabilization of the brain reward mechanism being linked to an increased risk of DE relapse.14 Note, the higher frequency of cardiovascular disorders than in other patients is also associated with the decrease in the activity of GDH, the glutamate-metabolizing enzyme
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For example, HO-1, which is sensitive to oxidative stress, contributes to the production of bilirubin, a powerful physiological antioxidant (Drummond et al
It's important to understand also that not every single person is gonna be starting from the same place when it comes to our glutathione status, our gut microbiome, our immune health
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