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Among the 5581 screened candidates, 3533 met the entry criteria and were randomly assigned to receive 1.0mg subcutaneous semaglutide weekly (1767 participants) or placebo (1766 participants)

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reactivity and possible clinical significance

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Atwood CS, Bowen RL

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Developed to provide the benefits of growth hormone release while minimizing unwanted hormonal side effects, Ipamorelin selectively stimulates growth hormone (GH) release from the pituitary gland without significantly affecting cortisol, prolactin, or thyroid-stimulating hormone levels

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Limitations including small sample sizes, heterogeneous populations, and lack of standardized protocols reduce the generalizability of current findings

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