The second conclusion to underline is that there was in each parameter a response with lower degree that observed in the former patient subgroup
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(PubMed) Ohara M, Ogawa K, Suda G, et al
Solvent : For reconstitution, use a slightly acidic buffer (pH ~4-5) to slow deamidation
5.1.3 Retinoids All trans retinoic acid (ATRA), isotretinoin, retinol, retinaldehyde, tazarotene, and adapalene are among retinoids used as depigmenting agents in melasma management