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It is not uncommon for patients with these genetic polymorphism's to be very sensitive to supplementation

A course of two at 90 spaced two to four weeks apart is a common starter for patients with a more depleted baseline, working out to 45 per session

Kim YC, Ahn JH, Jin H, Yang MJ, Hong SP, Yoon JH, et al

Cardiac output is markedly increased owing to increased stroke volume and rapid heart rate (186, 187)

(2004) Given the paired nature of the crossover design and the non-normal distribution of some variables, within-subject comparisons across treatment periods were performed using paired Wilcoxon Signed-Rank tests, with p-values adjusted for multiple comparisons using the BonferroniHolm method