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a 1 and A 2" are each independently selected from the group consisting of oxygen, sulfur, -C(Z)-, -C(Z)0-, -OC(Z)-, -N(R 4b )-, -C(Z)N(R 4b )-, -N(R 4b )C(Z)-, -OC(Z)N(R 4b ) -, -N(R 4b )C(Z)0-, -N(R 4b )C(Z)N(R 5b )-, -S(O)-, -S(0) 2 -, -N(R 4a )S(0) 2 -, -C(R 6b )(R 7b )-, -N(C CH )-, -N(CH 2 C CH)-, CrC 12 alkylene, and CrC 12 alkyeneoxy, where Z is oxygen or sulfur

Practical Interpretation The mechanistic plausibility (NNMT NAD SIRT1/PGC-1 BMR & fat oxidation) is strong and consistent across preclinical models

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Liu iu tr tch cc (nng): 600mg 1200mg/ngy