Abrupt corticosteroid reduction can cause adrenal crisis and lupus flare
For subcutaneous tirzepatide injections, the recommended range is 29-gauge to 31-gauge, with 30-gauge being the most popular choice that balances comfort with easy medication flow
Results of STEP 1-4 were published this spring: STEP 1 tested a 2.4 mg weekly injection of semaglutide plus lifestyle intervention in 1,961 patients without diabetes
The choice is always one agent, titrated
Hum Reprod 20:373381 Rubino F, Cummings DE, Eckel RH, Cohen RV, Wilding JPH, Brown WA, Stanford FC, Batterham RL, Farooqi IS, Farpour-Lambert NJ, le Roux CW, Sattar N, Baur LA, Morrison KM, Misra A, Kadowaki T, Tham KW, Sumithran P, Garvey WT, Kirwan JP, Fernndez-Real JM, Corkey BE, Toplak H, Kokkinos A, Kushner RF, Branca F, Valabhji J, Blher M, Bornstein SR, Grill HJ, Ravussin E, Gregg E, Al Busaidi NB, Alfaris NF, Al Ozairi E, Carlsson LMS, Clment K, Desprs JP, Dixon JB, Galea G, Kaplan LM, Laferrre B, Laville M, Lim S, Luna Fuentes JR, Mooney VM, Nadglowski J Jr., Urudinachi A, Olszanecka-Glinianowicz M, Pan A, Pattou F, Schauer PR, Tschp MH, van der Merwe MT, Vettor R, Mingrone G (2025) Definition and diagnostic criteria of clinical obesity
