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aureus (MRSA), as well as Escherichia coli and Pseudomonas aeruginosa

In general mB12/LDFA has a significant influence on redox regulation with medium effect sizes, particularly in the role of positively affecting glutathione metabolism and its precursors, whereas BH4 primarily has a positive effect on markers of oxidative damage as well as methylation metabolism with large effect sizes

Key safety principles include strict sterile technique to prevent contamination and infection, proper injection site preparation and rotation, correct needle insertion angle and depth for chosen administration route (IM or SC), slow administration to minimize discomfort, and appropriate post-injection site care and monitoring

doi: 10.1007/s00018-019-03039-y 101 BaoXZhangJHuangGYanJXuCDouZet al